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Genetic Epidemiology of Adult Brain Tumors

18 Years
Open (Enrolling by invite only)
Brain Neoplasm, Primary, Brain Neoplasms, Malignant, Brain Neoplasms, Benign

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Trial Information

Genetic Epidemiology of Adult Brain Tumors

Primary Objective:

The primary objective of this research is to establish a clinic-based case-control study for
examination of potential risk factors for primary adult brain tumors. After assembling a
series of 1,500 cases and 3,000 controls, investigators will test current hypotheses on
ge-netic and environmental risk factors for the occurrence of these tumors.


In this case-control study, persons with a recent diagnosis (within 4 months) of a primary
brain tumor will be identified in the neurology/neurosurgery clinics at major treatment
referral centers in the Southeast. Non-blood related relatives (eg. in-laws), friends or
other persons will be recruited as controls. Names and contact information of eligible
controls will be ascertained from patients. A total of 1,500 cases and 3,000 controls will
be enrolled over the course of the 5-year study. All enrolled subjects will complete a one
hour interview on lifestyle, environmental exposures, diet, physical activity, tobacco use
and medical history. They will also be asked to provide a DNA sample, a water sample and a
toenail sample (from each great toe). At the end of data collection, lifestyles and genetic
attributes will be compared in cases and controls to identify any differences that may be
relevant to the causation of disease. Because the study will recruit patients near the time
of disease diagnosis, full enrollment should be possible. In addition, high re-sponse rates
are anticipated among the controls. Thus, with the large numbers of patients available and
high anticipated response rates, the study offers a unique opportunity to successfully
identify environmental and genetic risk factors for this uncommon form of cancer.

Inclusion Criteria:

- Case: Incident primary glioma or meningioma of any stage, diagnosed within 4 months.

- Control: non-blood relative, friend, co-worker of same gender as case

- Aged 18 and older; either gender; any race

Type of Study:


Study Design:


Principal Investigator

Kathleen M. Egan, DSc

Investigator Role:

Principal Investigator

Investigator Affiliation:

H. Lee Moffitt Cancer Center


United States: Institutional Review Board

Study ID:




Start Date:

October 2003

Completion Date:

July 2012

Related Keywords:

  • Brain Neoplasm, Primary
  • Brain Neoplasms, Malignant
  • Brain Neoplasms, Benign
  • Brain Neoplasms
  • Neoplasms



University of Alabama at BirminghamBirmingham, Alabama  35294-3300
H. Lee Moffitt Cancer CenterTampa, Florida  33612
Emory UniversityAtlanta, Georgia  30322
Vanderbilt University Medical Center, Department of Neurological SurgeryNashville, Tennessee  37232
Kentuckaina Cancer InstituteLouisville, Kentucky  40202