Carotid Artery Disease in Long-Term Survivors of Childhood Cancer
Some research shows that survivors of adult head or neck cancer, who received radiation
therapy, are at increased risk for thickening or blockage of the carotid arteries, which may
increase the risk for other medical conditions, such as stroke. Researchers want to learn
about the possible risks of thickening or blockage of the carotid arteries in survivors of
childhood head or neck cancer.
If you agree to take part in this study, researchers will see if there are any possible
effects (thickening or blockage) of radiation therapy on your carotid arteries. This will be
done by examining the test results from routine testing (mentioned below) that is normally
done for your standard long-term follow-up care of the disease. These routine tests would be
performed even if you were not in this research study.
During your long-term follow-up clinic appointment, you will have a physical exam and an
ultrasound test (performed at the Cardiology Clinic) of the carotid arteries. A carotid
ultrasound is a test that uses sound waves to look at the blood vessels in the neck. Blood
will be drawn (about 2-3 teaspoons) for laboratory tests, including blood sugar level, blood
cholesterol level, blood triglyceride level, thyroid hormone level, and blood levels of
certain proteins (C-reactive protein and brain natriuretic peptide).
If any of the tests show any thickening or blockage of the carotid arteries or other medical
problems, such as high blood sugar, your study doctor will discuss the test results,
treatment options, and/or a follow-up plan with you.
This is an investigational study. Up to 60 patients will take part in this study. All will
be enrolled at M. D. Anderson.
Observational Model: Cohort, Time Perspective: Prospective
Patients with Carotid intima-media thickening (IMT)
Carotid ultrasound testing and laboratory examinations performed at time of routinely scheduled yearly appointment.
Winston Huh, MD
M.D. Anderson Cancer Center
United States: Institutional Review Board
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