Inclusion Criteria:

Patients Must:

1. Have histologically proven malignant glioma (anaplastic astrocytoma, anaplastic
oligodendroglioma or glioblastoma multiforme) which is progressive or recurrent after
external beam radiation therapy (to at least 50 Gy) ± chemotherapy. Patients with
previous low grade glioma who progressed after radiotherapy ± chemotherapy and are
biopsied and found to have a high grade glioma are eligible.

2. Be ≥18 years of age.

3. Have a baseline Karnofsky Performance status of ≥60%

4. Have a Mini Mental State Exam score ≥ 19.

5. Have a life expectancy, based on the Investigator's judgment, of >3 months.

6. On screening ECG, have a QTc interval of <450 ms.

7. If taking steroids, be on a dose that is stable for at least 5 days prior to the
imaging dose.

8. Have recovered from the toxicity of all previous therapy prior to enrollment. If the
patient has undergone recent major surgery, an interval of at least 3 weeks must have
elapsed between the surgery and the date of the imaging dose.

9. Have adequate organ and marrow function as defined below:

hemoglobin >9.0g/dL absolute neutrophil count >1,500 mm3 platelet count >100,000 mm3
prothrombin time <1.5 ULN partial thromboplastin time (PTT) <1.5 ULN total
bilirubin < 2.0 mg/dL AST(SGOT)/ALT(SGPT) <5 x institutional ULN creatinine (serum)
≤2.0 mg/dL*

*If serum creatinine is >2.0 then creatinine clearance must be ≥60 ml/min

10. Have a negative serum and urine pregnancy test within 14 days of study drug
administration, if female and of child bearing potential.

11. Agree to use an effective form of contraception to avoid pregnancy, if fertile
(applicable to both male and female patients).

12. Agree to refrain from nursing, if female.

13. Have signed and dated written informed consent.

14. Be able to comply with treatment plan, study procedures and follow-up examinations.

Exclusion Criteria:

Patients may NOT:

1. Have a serious concurrent infection or medical illness which would jeopardize the
ability of the patient to receive the treatment outlined in this protocol with
reasonable safety. (Examples of medical illnesses are [but not limited to] the
following: uncontrolled hypertension, symptomatic congestive heart failure, unstable
angina pectoris, cardiac arrhythmia, or psychiatric illness/social situation that
would limit compliance with study requirements.)

2. Have a prior malignancy with less than 5-year disease free interval, except for
adequately treated basal cell or squamous cell carcinoma of the skin, or in situ
cancer of the cervix.

3. Be pregnant or breast-feeding.

4. Have received radiation treatments ≤ 3 months from time of first study drug
administration.

5. Have received any cytotoxic chemotherapy, whether conventional or investigational, ≤
4 weeks prior to enrollment in this study (6 weeks for mitomycin-C or nitrosoureas).

6. Have a history of allergic reactions attributed to compounds of similar chemical or
biologic composition to 131I-TM-601 e.g. iodine or iodine-containing drugs.