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The Effect of Ablation Therapy on Barrett's Esophagus

18 Years
90 Years
Open (Enrolling)
Barrett's Esophagus, Early Esophageal Adenocarcinoma

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Trial Information

The Effect of Ablation Therapy on Barrett's Esophagus

To assess the effect of ablation therapy on Barrett's esophagus. Proposal Ablation therapy
is an FDA approved treatment to decrease cancer risk in Barrett's esophagus mucosa. This is
being performed in our Barrett's Esophagus Unit on a regular basis. However, the longterm
outcomes of this therapy is not established and there are patients who have been treated who
later re-develop Barrett's mucosa. This study will allow us store tissue samples that can
later be used to assess the effect of ablative therapy on Barrett's esophagus.

Inclusion Criteria:

- Patients who have had or qualify for ablation therapy for treatment of their
barrett's esophagus with high grade dysplasia or early esophageal adenocarcinoma

- Ability to provide informed consent

Exclusion Criteria:

- Eastern Cooperative Oncology Group performance status 3 or 4

- Inability to tolerate endoscopic procedures

- Pregnancy: Females of child-bearing age will be screened with pregnancy test.

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Response to treatment

Outcome Description:

presence of persistent or recurrence of barrett's esophagus and/or dysplasia

Outcome Time Frame:

at time of surveillance intervals

Safety Issue:


Principal Investigator

Kenneth K Wang, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Mayo Clinic


United States: Institutional Review Board

Study ID:




Start Date:

January 2004

Completion Date:

January 2015

Related Keywords:

  • Barrett's Esophagus
  • Early Esophageal Adenocarcinoma
  • Photodynamic Therapy
  • Barrett's Esophagus
  • Early Esophageal Adenocarcinoma
  • Adenocarcinoma
  • Adenocarcinoma, Mucinous
  • Barrett Esophagus
  • Esophageal Diseases



Mayo Clinic Rochester, Minnesota  55905