Inclusion Criteria:

1. Patients must be 19 years of age or older.

2. Patients must have histologically proven newly diagnosed glioblastoma multiforme.

3. Patients must have fully recovered from the immediate post-operative period and be
maintained on a stable corticosteroid regimen for 5 days prior to entry.

4. Patients must have a Karnofsky performance status > 60% (i.e. the patient must be
able to care for himself/herself with occasional help from others).

5. Patients must have adequate hematologic, renal and liver function (i.e. Absolute
neutrophil count > 1500/mm3, Platelets > 100,000/mm3, creatinine 1.5 mg/dl .

6. Women of childbearing potential must have a negative pregnancy test.

7. Patients with the potential for pregnancy or impregnating their partner must agree to
follow acceptable birth control methods to avoid conception. The effect of the
investigational drugs on the developing human fetus is not known, but these drugs are
likely to be harmful to the developing fetus or nursing infant. Women of
child-bearing potential must agree to use adequate contraception (either surgical
sterilization; approved hormonal contraceptives such as birth control pills
Depo-Provera, or Lupron Depot; barrier methods such as condom or diaphragm along with
spermicide; or an Intrauterine device (IUD)). Should a woman become pregnant or
suspect she is pregnant while participating in this study, she should inform her
treating physician and study PI immediately.

8. The patient is able to self-administer or has a caregiver who can reliably administer
subcutaneous injections.

9. Ability to understand and the willingness to sign a written informed consent
document.

Exclusion Criteria:

1. Pregnant or breast feeding.

2. Prior therapy for the brain tumor (except surgery)

3. Prior treatment with antineoplastic agents.

4. Exclude sexually active males and females unwilling to practice contraception during
the study.

5. Serious concurrent infections.

6. Clinically significant cardiac disease not well controlled with medication (e.g.
congestive heart failure, symptomatic coronary artery disease and cardiac arrhythmias
) or myocardial infarction within the last 12 months.

7. Patients who have had prior cytotoxic chemotherapy prior to radiation therapy.

8. Patients with other serious uncontrolled co-morbid diseases that the investigator
feels may comprise the study findings.

9. Patients must be able to learn to self -administer or have another person administer
subcutaneous(SQ) injections.

10. Patients who have received any other investigational agents within the 28 days prior
to Day 1 of the study.

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