Quantitative Dynamic Contrast Enhanced Breast MRI
Our aim is to perform dynamic contrast enhanced (DCE) MRI on 150 patients during their
routine breast MRI examination at MSKCC. This will add extra 10 min scanning time to the
routine examination. High resolution (submillimeter) parametric maps of pathophysiologic
quantities, such as tumor vessel permeability, tumor perfusion, extracellular extravascular
volume fraction, will be generated from the DCE MRI data. These results will be correlated
with pathology to determine new pharmacokinetic threshold so that the negative predictive
value for benign lesions is close to 100%. The improvement in diagnostic specificity may
help to reduce unnecessary biopsies in the future.
Observational Model: Case-Only, Time Perspective: Prospective
To assess whether the new quantitative MRI method can discriminate between malignant and nonmalignant breast lesions among the lesions seen in conventional MRI.
Sunitha Thakur, PhD
Memorial Sloan-Kettering Cancer Center
United States: Institutional Review Board
|Memorial Sloan-Kettering Cancer Center||New York, New York 10021|