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Adherence to Comprehensive, Multi-Organ Screening Recommendations in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients


N/A
18 Years
N/A
Open (Enrolling)
Both
Hereditary Nonpolyposis Colorectal Cancer, Colon Cancer

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Trial Information

Adherence to Comprehensive, Multi-Organ Screening Recommendations in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients


Inclusion Criteria:



- A patient will be eligible for enrollment if he/she is self-referred or
physician-referred for genetic counseling at Memorial Sloan-Kettering Cancer Center's
(MSKCC) Clinical Genetics Service due to a concern about increased risk for colon
cancer or;

- An individual who presents for genetic counseling at MSKCC's Clinical Genetics
Service after undergoing genetic testing at an outside institution with a documented
mutation in any gene associated with HNPCC or;

- An individual who in the context of genetic counseling has received stricter
colorectal and/or gynecologic screening recommendations than that of the general
population regardless of genetic test results.

- DNA of patients who have been consented to protocol 93-102 ("Ascertainment of
Peripheral Blood or Saliva Samples for Genetic Epidemiology Studies of Familial
Cancers"), who meet the eligibility criteria listed above, will also be eligible for
inclusion in this study.

Exclusion Criteria:

- Patients will be excluded from this study if: he/she has physical, cognitive or
psychiatric conditions that interfere with ability to give meaningful informed
consent; he/she cannot read, write or communicate in English; he/she is less than 18
years of age; he/she has received a diagnosis of FAP.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

To assess adherence to comprehensive, multi-organ screening and risk-reducing behavior recommendations in HNPCC patients.

Outcome Time Frame:

conclusion of study

Safety Issue:

No

Principal Investigator

Zsofia Stadler, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

04-144

NCT ID:

NCT00582296

Start Date:

December 2004

Completion Date:

December 2013

Related Keywords:

  • Hereditary Nonpolyposis Colorectal Cancer
  • Colon Cancer
  • Lynch syndrome
  • Colonic Neoplasms
  • Colorectal Neoplasms
  • Colorectal Neoplasms, Hereditary Nonpolyposis

Name

Location

Memorial Sloan Kettering Cancer CenterNew York, New York  10021