Prospective Study of Possible Infectious Disease - Associated Antigen Drive in Previously Untreated Indolent Lymphoma
This is a prospective observational clinical study of possible infectious disease-associated
antigen drive in previously untreated patients with indolent lymphoma (follicular and
Eligible patients with a new diagnosis of indolent lymphoma will be enrolled after informed
consent. All patients will be tested for possible known infectious diseases that may
contribute to antigen drive (H. Pylori; Hepatitis C), as well as for other infectious
diseases not yet established as contributing to antigen drive (Borrelia; Chlamydia; and
small bowel overgrowth). All patients will have a complete history recorded regarding other
possible chronic infections, and an infectious disease consultation, as indicated.
Patients with positive antigen-drive infectious disease studies will be treated as indicated
with standard antibiotic regimens and response (both infectious disease as well as lymphoma
status)will be documented and recorded.
The primary objective of this study is (1) to evaluate the possible association of
infectious diseases in previously untreated patients with indolent lymphoma. The secondary
objective of this study is to evaluate possible lymphoma response the in patients treated
for positive infectious disease studies; and to evaluate EBV immune responses in these
previously untreated patients.
Observational Model: Cohort, Time Perspective: Prospective
5 years 10 months
Carol Portlock, MD
Memorial Sloan-Kettering Cancer Center
United States: Food and Drug Administration
|Memorial Sloan-Kettering Cancer Center||New York, New York 10021|