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Spectroscopy With Surface Coils and Decoupling

18 Years
Open (Enrolling)
Adrenal Cortical Cancer, Brain Cancer, Breast Cancer, CNS Cancer, Colon Cancer, HEENT Cancer, Hodgkin's Disease, Kaposi's Sarcoma, Liver Cancer, Lung Cancer, Non-Hodgkin's Lymphoma, Ovarian Cancer, Pancreatic Cancer, Prostate Cancer, Rectal Cancer, Renal Cancer, Sarcoma, Squamous Cell Carcinoma, Thyroid Cancer

Thank you

Trial Information

Spectroscopy With Surface Coils and Decoupling

The investigators propose to use 1H spectroscopy or 1H decoupled 31P NMR spectroscopy to
obtain biochemical information about tumor metabolism in patients, both before and after
antineoplastic therapy. In healthy volunteers, normal tissue metabolism will also be
studied. It is hypothesized that metabolic information may be of prognostic significance, or
may be useful for timing of therapy.

Inclusion Criteria:

- Patients must have suspected or documented neoplastic disease, strongly suspected or
established by physical examination, history or conventional histologic biochemical
or imaging techniques, or have surgical or aspiration biopsy that will be used to
establish a diagnosis

- Patients with obstructive jaundice, both from malignant and non-malignant disease,
will be considered for the study

- Patients/volunteers must be clinically stable and not require cardiovascular

- Patients must be 6 years of age or older and be able to cooperate for an
approximately 60 minute examination

- Volunteers must be 18 years of age or older

Exclusion Criteria:

- Inability to cooperate for an MR exam

- Contraindication to MR: Pacemaker, Aneurysmal clips Any ferrous metallic implants
which could be deflected by the magnet, Metal implants in field of view, Pregnant
women, OR Age and mental status wherein he/she is unable to cooperate for MR study

Type of Study:


Study Design:

Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

To obtain high resolution spectra from tumors using surface coils to improve sensitivity.

Outcome Time Frame:

2 years

Safety Issue:


Principal Investigator

Jason Koutcher, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center


United States: Food and Drug Administration

Study ID:




Start Date:

February 1997

Completion Date:

February 2014

Related Keywords:

  • Adrenal Cortical Cancer
  • Brain Cancer
  • Breast Cancer
  • CNS Cancer
  • Colon Cancer
  • HEENT Cancer
  • Hodgkin's Disease
  • Kaposi's Sarcoma
  • Liver Cancer
  • Lung Cancer
  • Non-Hodgkin's Lymphoma
  • Ovarian Cancer
  • Pancreatic Cancer
  • Prostate Cancer
  • Rectal Cancer
  • Renal Cancer
  • Sarcoma
  • Squamous Cell Carcinoma
  • Thyroid Cancer
  • Brain Neoplasms
  • Breast Neoplasms
  • Carcinoma
  • Colonic Neoplasms
  • Rectal Neoplasms
  • Thyroid Neoplasms
  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Carcinoma, Squamous Cell
  • Hodgkin Disease
  • Liver Neoplasms
  • Lung Neoplasms
  • Lymphoma
  • Lymphoma, Non-Hodgkin
  • Ovarian Neoplasms
  • Pancreatic Neoplasms
  • Prostatic Neoplasms
  • Sarcoma, Kaposi
  • Central Nervous System Neoplasms
  • Sarcoma



Memorial Sloan-Kettering Cancer Center New York, New York  10021