Inclusion Criteria:

- For acquisition of intra-operative brain or spine tumor specimens, blood specimens
and spinal fluid specimens, all patients who undergo surgery for resection or biopsy
qualify for inclusion in this protocol.

- If spinal fluid is not accessed as part of the operative procedure, it will not be
collected.

- All patients must be under the care of one or more members of the MSKCC CNS disease
management team at the time of tissue acquisition. Patients may have been previously
diagnosed and/or treated at another institution.

- Subjects are eligible regardless of sex, age or race.

- Parental or guardian consents will be obtained in the case of minors (less than 18
years of age)

Exclusion Criteria:

- Patients or their guardians, in case of a minor, may choose to be excluded at any
time.

- If a patient, or guardian, decides to withdraw after some or all of the tissues have
been collected, such tissues will be destroyed at their request.

- Patients or their guardians will be counseled at the time of obtaining their consent,
of the possibility of withdrawing from the protocol.