Chemotherapy Resistance in Osteogenic Sarcoma and Other Solid Tumors
When tumor tissue known or presumed to be a primary or secondary bone cancer or solid tumor
with known elevated intra-tumoral pressure such as retinoblastoma is being removed or has
been removed for diagnostic or therapeutic reasons a small sample of it will be obtained for
this study. The tumor samples will be used to study in vitro, determinants of chemotherapy
resistance and oncogenesis. These determinants will be correlated with histologic response
to preoperative chemotherapy and clinical outcome (event free survival). In addition, blood
samples (20ml) may be obtained before or after the procedure.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
To test tumor samples obtained from patients with primary or secondary bone cancer for mechanisms of acquired and intrinsic resistance to methotrexate and to relate these findings to histologic response to preoperative chemotherapy and outcome.
John Healey, MD
Memorial Sloan-Kettering Cancer Center
United States: Institutional Review Board
|Memorial Sloan-Kettering Cancer Center||New York, New York 10021|