Inclusion Criteria:

- No age or gender limit, though minimal weight limitations for apheresis is about 15 -
20 Kg.

- Both male and female of childbearing age entering the protocol must use a medically
accepted form of birth control during the study, will be required to have a negative
pregnancy test for female.

- patients with atypical malignant brain tumor will be eligible.

- Patients must have a Karnofsky performance score of at least 60%

- patients may be maintained on glucocorticoid therapy at the lowest possible dose.

- Baseline hematologic studies and chemistry profiles must meet the criteria.

- Tumor specimen of adequate size to yield protein concentration in sufficient
quantity.

- Tumor-lysate peptide must be generated in sufficient quantity to pulse the APC's for
vaccination.

- Patient must have no prior sensitivity to the components of the dendritic cell
vaccine.

- Patient must agree to consider an autopsy in the event of death in an attempt to
learn more concerning the nature of this treatment and tumor biology.

- Patient must be capable of signing IRB approved Research Consent and Release of
medical Records form.

Exclusion Criteria:

- Severe pulmonary, cardiac or other systemic disease associated with an unacceptable
anesthetic or operative risk.

- The presence of an acute infection requiring active treatment will be criteria for
delay or exclusion.

- Patients with a known history of an autoimmune disorder.

- Inability to give informed consent.

- Pregnancy.