Inclusion Criteria:

- Patients must have a histopathological diagnosis of malignant glioma

- Patients must have undergone surgery and placement of Gliadel wafer.

- Women of child bearing potential must use medically accepted form of birth control.

- A Karnofsky performance status of at least 60%

- Must be off of steroid at least two weeks prior to vaccination

- Hematologic and metabolic panel results will be within the parameters of the
protocol.

- Must be capable of IRB approved Informed Consent.

Exclusion Criteria:

- Patients with systemic disease

- Presence of acute infection

- Contraindication to MRI

- Known history of autoimmune disorder

- Pregnancy

- Positive for hepatitis B, C, HIV, syphilis, HTLVa nd HCV

- Allergic to Gentamicin.

- Inability to participate as per Principal Investigator's discretion.