A Phase II Study of Spinal Radiosurgery
Optimal radiation plan is generated that treats the tumor (CTV) and spares normal tissue,
especially the spinal cord. Motion and QA study will determine intrafraction motion for
phase II portion of the study.
Dose prescription to tumor is based upon maximal dose received by 0.5 cc of spinal cord and
whether patient has had prior radiation therapy to that area:
Phase I - Motion and QA Study: 20-25 Gy in 5 fractions/10-20 patients/previous RT = <50% CTV
dose/No previous RT = <80% CTV dose.
Phase II - 9-24 Gy in 1 fraction/30 total in order to have 20 evaluable patients (15
patients with prior RT and 15 without prior RT/previous RT = 8 Gy/No previous RT = 10 Gy.
# Motion and QA study will treat CTV to 20-25 Gy in 5 fractions to study intrafraction
motion for QA of single fraction administration. This will define treatment margins for
single fraction radiosurgery.
- greater than six months since completion of RT
- at least 20 Gy, but no more than 50 Gy
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
To determine intrafraction target motion and define quality assurance procedures for single fraction spinal radiosurgery
John B. Fiveash, M.D.
University of Alabama at Birmingham
United States: Institutional Review Board
|University of Alabama at Birmingham/The Kirklin Clinic at Acton Road||Birmingham, Alabama 35233|