Inclusion Criteria:

1. Patient with recurrent or metastatic osteosarcoma who is considered refractory to
known therapies.

2. Histologically or cytologically confirmed osteosarcoma that is measurable.

3. Adequate hepatic function: Total bilirubin < 2.0 mg/dL (upper limit included);
AST/ALT < 2x institutional norm; alkaline phosphatase < 2.5x upper limit of
institutional norm unless the patient has extensive bone metastases. Patients with
elevated alkaline phosphatase due to extensive liver disease will be excluded from
study; albumin > 3.0 mg/dL. There must be no substantial ascites. PT and PTT must be
within normal limits.

4. Performance status must be < 1 (ECOG 0-1) with a life expectancy of at least 3
months.

5. Hemoglobin > 9 gms%

6. Absolute granulocyte count > 1000/uL, and platelet count > 100,000/uL.

7. Serum creatinine of less than 1.5 mg%.

8. There must be no plans for the patient to receive further cancer therapy from the
date of enrollment until the completion of the 6-week follow-up visit.

9. Accessibility of peripheral or central IV line

10. Age > 10 years

11. Patients will be off chemotherapy for a minimum of 4 weeks prior to initiation of
therapy and should have recovered to Grade 1 or less toxicity.

12. The ability to understand and the willingness to sign a written informed consent
document.

Exclusion Criteria:

1. Prior malignancy, except for non-melanoma skin cancer, stage 1 breast cancer, CIS of
cervix from which the patient has been disease-free for 5 years.

2. Woman who are pregnant or nursing

3. Fertile patients unless they agree to use barrier contraception (condoms and
spermicide jelly) during the vector infusion period and for six weeks after infusion.
Male patients must agree to use barrier contraception.

4. Patients who are transfusion dependent (more than one transfusion per month)

5. Patients with medical, psychiatric, or social conditions that would compromise
successful adherence to this protocol.

6. Patient who do not meet the inclusion criteria.