Inclusion Criteria:

- Histologically confirmed pancreatic cancer.

- Measurable disease.

- Absence of ascites or obstructive jaundice.

- ECOG Performance Status 0-2.

- Adequate liver kidney and bone marrow function.

- Written informed consent.

Exclusion Criteria:

- Chronic diarrheic syndrome.

- Uncontrolled brain metastases after radiation.

- Liver infiltration over 50%.

- Peripheral neuropathy ≥ 2.

- No second primary malignancy within the past 5 years, except non-melanomas skin
cancer or in situ carcinoma of the cervix.

- No active uncontrolled infection.

- Active cardiac disease : unstable angina or onset of angina within last 3 months,
myocardial infarction within 6 months, congestive heart failure > class II, cardiac
ventricular arrhythmias requiring anti-arrhythmic therapy.

- Women who are pregnant or lactating.