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Prospective Randomized Study on Therapeutic Gain Achieved By Chemoradiation And/Or Accelerated Radiation For T3-4N0-1M0 Nasopharyngeal Carcinoma


N/A
N/A
70 Years
Not Enrolling
Both
Nasopharyngeal Neoplasms, Carcinoma, Squamous Cell

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Trial Information

Prospective Randomized Study on Therapeutic Gain Achieved By Chemoradiation And/Or Accelerated Radiation For T3-4N0-1M0 Nasopharyngeal Carcinoma


Inclusion Criteria:



- Undifferentiated or non-keratinizing carcinoma

- Tumor staged as T3-4 AND N0-1

- No evidence of distant metastasis (M0)

- Performance status: 0-2

- Marrow: WBC >= 4 and platelet = 100

- Renal: creatinine clearance = 60

- Informed consent

Exclusion Criteria:

- WHO type I squamous cell carcinoma or adenocarcinoma

- Age >= 70

- Palliative intent or tumor extent mandating AP opposing facio-cervical fields

- Prior malignancy except adequately treated basal cell or squamous cell skin cancer,
in situ cervical cancer, or other cancer for which the patient has been disease-free
for 5 years

- Previous radiotherapy (except non-melanomatous skin cancers outside the intended RT
treatment volume

- Previous chemotherapy

- Patient is pregnant or lactating

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Failure free survival rate

Outcome Time Frame:

5-year

Principal Investigator

Anne WM Lee, Dr

Investigator Role:

Principal Investigator

Investigator Affiliation:

Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital

Authority:

Hong Kong: Ethics Committee

Study ID:

L/M-78 to PYH 08/79

NCT ID:

NCT00563862

Start Date:

July 1999

Completion Date:

June 2007

Related Keywords:

  • Nasopharyngeal Neoplasms
  • Carcinoma, Squamous Cell
  • Nasopharyngeal Carcinoma
  • T3-4N0-1M0
  • Neoplasms
  • Carcinoma
  • Carcinoma, Squamous Cell
  • Nasopharyngeal Neoplasms

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