Inclusion Criteria:

- Patient must be at least 18 years of age, with adequate organ function, and an
Eastern Cooperative Oncology Group (ECOG) performance of <2

- Patient must be willing to undergo pre-study and post-dose tumor biopsy and have
tumor accessible for biopsy (Waived during Parts A and C)

Exclusion Criteria:

- Patient is currently using bisphosphonate therapy or has received this therapy in
past 6 months

- Patient has had chemotherapy, radiotherapy, or biological therapy within 4 weeks of
study participation

- Patient has history of cardiac disease

- Patient with a primary central nervous system tumor

- Patient has a known psychiatric or substance abuse disorder

- Patient is pregnant or breastfeeding, or expecting to conceive during the study

- Patient is known to be Human Immunodeficiency Virus (HIV) positive and the HIV
infection is not well controlled

- Patient has received therapy with a Proton-Pump Inhibitor, Histamine2-Receptor
antagonist or antacid within one week of study participation (Part B only)