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Monitoring Neural Tissues Properties by Modulated Imaging (MI)

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Brain Tumor

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Trial Information

Monitoring Neural Tissues Properties by Modulated Imaging (MI)

While compatible with time-modulation methods, MI alternatively uses spatially-modulated
illumination for imaging of tissue constituents.

The MI system consists of

1. a light projection system that illuminates the tissue with spatial sinusoid patterns.

2. a CCD camera which collects the diffusely reflected light in a non-contact geometry.
The wavelength of illumination can be selected by bandpass filtering of a broadband
source,or by use of a monochromatic source.

Lastly, tissue fluorescence measurements can be performed by placing a combination of
source-blocking and bandpass emission filters in front of the camera.

The diffusely reflected amplitude of the modulated wave carries both optical property
(absorption, fluorescence, scattering) and depth information. Specifically, the sampling
depth of the spatially-modulated wave is a function of the frequency of illumination and the
tissue optical properties.

During neurosurgery when nervous tissue is exposed by the attending neurosurgeon,
intraoperative pictures will be taken using the modulated imager (MI) by the investigators.

The imaging procedure may delay completion of the surgical case by an estimated 10 to 20
minutes. This is minimal prolongation considering most brain tumor resections take several

The images acquired will be processed after the surgical procedure and will not be available
to the surgeon during the operative procedure.

Inclusion Criteria:

- All nervous system tumor patients who undergo a preoperative MRI,and undergoing
central nervous system operative procedures for non tumor.

Exclusion Criteria:

- All emergency neurosurgical procedures.

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Principal Investigator

Mark Linskey, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Neurosurgery department,University of California,Irvine


United States: Institutional Review Board

Study ID:

LAMMP WIFI RR-01192-29



Start Date:

November 2008

Completion Date:

January 2012

Related Keywords:

  • Brain Tumor
  • Brain tumor
  • Brain Neoplasms



Beckman Laser Institute,University of California,Irvine Irvine, California  92612
Neurosurgery department,University of California,Irvine Orange, California  92868