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A Phase 1 Safety Evaluation of Oral Enzastaurin in Combination With Bevacizumab in Patients With Advanced/Metastatic Cancer


Phase 1
18 Years
N/A
Not Enrolling
Both
Unspecified Adult Solid Tumor, Protocol Specific

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Trial Information

A Phase 1 Safety Evaluation of Oral Enzastaurin in Combination With Bevacizumab in Patients With Advanced/Metastatic Cancer


OBJECTIVES:

- To determine the recommended phase II doses of enzastaurin hydrochloride and
bevacizumab that may be safely administered to patients with locally advanced or
metastatic malignancies.

- To characterize the toxicities of enzastaurin hydrochloride and bevacizumab in these
patients.

- To document the antitumor activity of enzastaurin hydrochloride and bevacizumab in
these patients.

- To evaluate the pharmacokinetics of enzastaurin hydrochloride and bevacizumab in these
patients.

- To assess GSK3β as a biomarker relevant to enzastaurin hydrochloride and its
correlation with clinical outcome in these patients.

OUTLINE: This is a dose-escalation study of enzastaurin hydrochloride and bevacizumab.

Patients receive oral enzastaurin hydrochloride once, twice, or three times daily on days
1-21 or days 1-28 and bevacizumab IV over 30-90 minutes on day 1 or days 1 and 15. Courses
repeat every 21 or 28 days in the absence of disease progression or unacceptable toxicity.

Blood samples are collected periodically during study for pharmacokinetic evaluation.
Samples are also analyzed for biomarker (GSK3β) by ELISA.

After completion of study treatment, patients are followed for 30 days.

National Cancer Institute (NCI) registered this trial with Eli Lilly as sponsor. NCI did
not update the record. In June 2012, NCI transferred the trial to Lilly's clinicaltrials.gov
account and Lilly updated the record with the trial status and trial completion dates. This
trial is not an applicable trial under Food and Drug Administration Amendments Act of 2007
(FDAAA).

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Histologic or cytologic diagnosis of locally advanced or metastatic cancer for which
no preferable therapy exists

- Measurable or nonmeasurable disease

- No CNS metastases or a primary CNS tumor

PATIENT CHARACTERISTICS:

- ECOG performance status 0-2

- Life expectancy ≥ 12 weeks

- WBC count ≥ 3.0 × 10^9/L

- Absolute neutrophil count ≥ 1.5 × 10^9/L

- Platelet count ≥ 100 × 10^9/L

- Hemoglobin ≥ 10 g/dL (6.21 mmol/L)

- Bilirubin ≤ 2 times upper limit of normal (ULN)

- Alkaline phosphatase ≤ 3 times ULN (5 times ULN if liver metastases are present)

- AST and ALT ≤ 3 times ULN (5 times ULN if liver metastases are present)

- Serum creatinine < 1.5 times ULN

- No proteinuria at baseline, as demonstrated by either of the following:

- Urine protein:creatinine ratio < 1.0 at screening

- Urine dipstick for proteinuria < 2+ (patients discovered to have ≥ 2+
proteinuria on dipstick urinalysis at baseline must undergo a 24-hour urine
collection that demonstrates ≤ 1 g of protein in 24 hours to be eligible for
study participation)

- No second primary malignancy that could affect compliance with the study or
interpretation of the study results

- No concurrent serious systemic disorder (e.g., active infection, including HIV) that,
in the opinion of the investigator, would compromise the patient's ability to adhere
to the study

- No known hypersensitivity to bevacizumab or enzastaurin hydrochloride, or to a
component of either drug

- No prior bevacizumab-related toxicity requiring discontinuation, such as a
thromboembolic event, hemorrhage, or serious hypertension

- No clinically significant cardiac disease, in the opinion of the investigator,
including any of the following:

- Myocardial infarction within the past 6 months

- Symptomatic angina pectoris

- Congestive heart failure not controlled by medications

- ECG abnormalities indicative of clinically significant cardiac disease

- No evidence of bleeding diathesis or coagulopathy

- No nonhealing cutaneous wound or gastrointestinal ulcer

- No history of or risk for abdominal fistula, gastrointestinal perforation, or
intra-abdominal abscess within the past 6 months

- No hemoptysis requiring medical attention within the past 3 months

- No known history of cerebrovascular accidents or transient ischemic attacks

- No clinically significant vascular or peripheral vascular disease

- No hypertension not controlled by medical management

- No history of hypertensive crisis or hypertensive encephalopathy

- No significant traumatic injury within the past 28 days

- Able to comply with study or study procedures

- Able to swallow tablets

- Exhibits compliance and geographic proximity that allow adequate follow-up

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for 3 months after
completion of study treatment

PRIOR CONCURRENT THERAPY:

- Recovered from prior therapy

- No prior participation in this study or any other study involving enzastaurin
hydrochloride

- At least 4 weeks since prior chemotherapy (6 weeks for mitomycin C or nitrosoureas)

- At least 4 weeks since prior radiotherapy, anticancer hormone therapy, or other
investigational therapy

- Patients with hormone-refractory prostate cancer receiving luteinizing
hormone-releasing hormone analogue therapy (leuprolide or goserelin) prior to
study enrollment should continue therapy during study participation

- At least 6 weeks since prior bicalutamide

- At least 4 weeks since prior flutamide or nilutamide

- More than 10 days since prior and no concurrent aspirin > 325 mg/day

- More than 28 days since prior major surgery or open biopsy

- More than 7 days since prior core biopsy or other minor surgical procedure, excluding
placement of a vascular access device

- No concurrent carbamazepine, phenobarbital, or phenytoin

- No concurrent systemic anticoagulation

- No concurrent chronic use of other nonsteroidal anti-inflammatory drugs

- No concurrent routine use of colony-stimulating factors

- No concurrent major surgery

- No other concurrent chemotherapy, radiotherapy, immunotherapy, or experimental
medications

- No other concurrent antitumor therapy

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Recommended phase II doses of enzastaurin hydrochloride and bevacizumab

Safety Issue:

Yes

Principal Investigator

Connie Collins, BSN

Investigator Affiliation:

Sidney Kimmel Comprehensive Cancer Center

Authority:

United States: Food and Drug Administration

Study ID:

11182

NCT ID:

NCT00550927

Start Date:

November 2006

Completion Date:

September 2012

Related Keywords:

  • Unspecified Adult Solid Tumor, Protocol Specific
  • unspecified adult solid tumor, protocol specific
  • Neoplasm Metastasis

Name

Location

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBaltimore, Maryland  21231-2410