Inclusion Criteria:

- Metastatic Stage IV disease, or Stage III disease that is not surgically resectable

- ECOG Performance Status of 0, 1, or 2

- Life expectancy of at least 12 weeks

- Adequate venous access

- Agreement to practice effective method of birth control

Exclusion Criteria:

- Less than 3 weeks of recovery from prior major surgery or other therapy, including
radiation therapy, chemotherapy, or immunotherapy, or cytokine, biologic, or vaccine
therapy

- Significant medical disease

- Known hypersensitivity to phosphorothioate-containing oligonucleotides

- Known hypersensitivity to DTIC

- Pregnancy/Lactation