Inclusion Criteria:

- Male or female patients , with congenital myasthenia, belonging to a previously
reported kindred diagnosed with COLQ deficiency.

Exclusion Criteria:

- History of allergy to Ephedrine or any inactive component.

- Significant abnormalities in screening Cardiovascular parameters (blood pressure,
pulse).

- Surgery within 6 weeks of screening.

- Concurrent use of any other medication except steroids.

- Pregnancy.

- Thyrotoxicosis.

- Co-morbid conditions or other neurological disorders that would confound assessment
of clinical parameters.

- Participation in another clinical trial within 30 days of study start.

- Patients who are non-cooperative or parents/ legal guardians who are unwilling to
sign consent form.