Know Cancer

or
forgot password

Descriptive Study Evaluating the Presence and Function of Natural Killer Cells in Elderly Patients With Acute Myeloid Leukemia in First Remission.


N/A
65 Years
N/A
Not Enrolling
Both
Leukemia

Thank you

Trial Information

Descriptive Study Evaluating the Presence and Function of Natural Killer Cells in Elderly Patients With Acute Myeloid Leukemia in First Remission.


OBJECTIVES:

Primary

- Determine the evolution of functional receptors of natural killer (NK) cells after
completion of chemotherapy in elderly patients with acute myeloid leukemia in first
remission.

Secondary

- Measure the kinetics of cytotoxic functional recovery of NK cells.

- Determine activation markers of NK cells.

OUTLINE: This is a multicenter study.

Patients receive 1 course of consolidation therapy comprising an anthracycline and
cytarabine to induce first remission.

Blood is collected on day 0 of the consolidation course and then every 2 weeks for 8 weeks.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of acute myeloid leukemia

- No promyelocytic leukemia

- No prior therapy

PATIENT CHARACTERISTICS:

- Hemoglobin > 10 g/dL

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Interventional

Study Design:

Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Evolution of functional natural killer (NK) cells after chemotherapy

Safety Issue:

No

Principal Investigator

Norbert Vey, MD

Investigator Affiliation:

Institut Paoli-Calmettes

Authority:

United States: Federal Government

Study ID:

CDR0000564106

NCT ID:

NCT00540956

Start Date:

November 2006

Completion Date:

Related Keywords:

  • Leukemia
  • untreated adult acute myeloid leukemia
  • adult acute megakaryoblastic leukemia (M7)
  • adult acute minimally differentiated myeloid leukemia (M0)
  • adult acute monoblastic leukemia (M5a)
  • adult acute monocytic leukemia (M5b)
  • adult acute myeloblastic leukemia with maturation (M2)
  • adult acute myeloblastic leukemia without maturation (M1)
  • adult acute myelomonocytic leukemia (M4)
  • adult erythroleukemia (M6a)
  • adult pure erythroid leukemia (M6b)
  • adult acute myeloid leukemia with 11q23 (MLL) abnormalities
  • adult acute myeloid leukemia with inv(16)(p13;q22)
  • adult acute myeloid leukemia with t(16;16)(p13;q22)
  • adult acute myeloid leukemia with t(8;21)(q22;q22)
  • Leukemia
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid

Name

Location