Descriptive Study Evaluating the Presence and Function of Natural Killer Cells in Elderly Patients With Acute Myeloid Leukemia in First Remission.
- Determine the evolution of functional receptors of natural killer (NK) cells after
completion of chemotherapy in elderly patients with acute myeloid leukemia in first
- Measure the kinetics of cytotoxic functional recovery of NK cells.
- Determine activation markers of NK cells.
OUTLINE: This is a multicenter study.
Patients receive 1 course of consolidation therapy comprising an anthracycline and
cytarabine to induce first remission.
Blood is collected on day 0 of the consolidation course and then every 2 weeks for 8 weeks.
- Diagnosis of acute myeloid leukemia
- No promyelocytic leukemia
- No prior therapy
- Hemoglobin > 10 g/dL
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Masking: Open Label, Primary Purpose: Treatment
Evolution of functional natural killer (NK) cells after chemotherapy
Norbert Vey, MD
United States: Federal Government
- untreated adult acute myeloid leukemia
- adult acute megakaryoblastic leukemia (M7)
- adult acute minimally differentiated myeloid leukemia (M0)
- adult acute monoblastic leukemia (M5a)
- adult acute monocytic leukemia (M5b)
- adult acute myeloblastic leukemia with maturation (M2)
- adult acute myeloblastic leukemia without maturation (M1)
- adult acute myelomonocytic leukemia (M4)
- adult erythroleukemia (M6a)
- adult pure erythroid leukemia (M6b)
- adult acute myeloid leukemia with 11q23 (MLL) abnormalities
- adult acute myeloid leukemia with inv(16)(p13;q22)
- adult acute myeloid leukemia with t(16;16)(p13;q22)
- adult acute myeloid leukemia with t(8;21)(q22;q22)
- Leukemia, Myeloid, Acute
- Leukemia, Myeloid