Trial Information
Prevention of Contrast Induced Nephropathy in Oncology Patients With Sodium Bicarbonate
Inclusion Criteria:
- > 18 years old
- cancer diagnosis
- GFR < 60 and > 30 ml/min/1,73m2 by MDRD formula or diabetic
- CT with contrast
Exclusion Criteria:
- dialysis needed
- uncontrolled hypertension
- changes in serum creatinine levels of at least 0.5 mg/dl during the previous 24 hours
of procedure
- recent exposure to radiographic contrast agents (within previous two days of the
study)
- administration of dopamine, mannitol , fenoldopam or N-Acetyl Cystein during the
intended time of study
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
Outcome Measure:
Development of contrast-induced nephropathy, defined as an increase in serum creatinine of 25% or more within 2 day after administration of contrast or dialysis needed
Outcome Time Frame:
2 days
Safety Issue:
No
Principal Investigator
Ricardo G Silva, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Hospital do Cancer de Barretos - Fundação PIO XII
Authority:
Brazil: National Committee of Ethics in Research
Study ID:
1-Silva
NCT ID:
NCT00540904
Start Date:
September 2007
Completion Date:
September 2009
Related Keywords:
- Contrast Induced Nephropathy
- contrast
- nephropathy
- bicarbonate
- prevention
- Kidney Diseases