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Optical Biopsy of Human Skin in Conjunction With Laser Treatment


N/A
18 Years
75 Years
Not Enrolling
Both
Malignant Melanoma,, Merkel Cell Carcinoma,, Basal Cell Carcinoma,, Squamous Cell Carcinoma, Atypical Nevi,, Congenital Nevi, Seborrheic Keratosis,, Paget's Disease, Dermatofibroma,, Kaposi's Sarcoma, Hypervascular Congenital Malformations, Port Wine Stain, Hemangioma, Tattoos, Scleroderma, Burns, Normal Skin

Thank you

Trial Information

Optical Biopsy of Human Skin in Conjunction With Laser Treatment


Procedure;

PMS,optical probe consisting of a pen shape plastic casing, optical fibers and a detector
will be placed on the study skin.The unique functional information provided by PMS makes it
well suited to characterizing vascular lesions and response to therapy. Measurements are
performed using a non-invasive, multi-wavelength, diode-laser PMS device. The measurements
provide quantitative optical property values that reflect changes in tissue perfusion,
oxygen consumption, and cell/matrix development. Each measurement requires less than 5
minutes to execute. The measurements will be taken before and after skin treatment.

MI,multispectral device uses a near-infrared tungsten-halogen bulb with heat filtering for
tissue illumination. This is analogous to illumination with a bright flashlight, and will
not inflict any pain or injury to the rat during the procedure. A CCD camera will capture
the reflected light of various spatial illumination patterns over an area of the study skin
surface.The images will be taken before and after skin treatment.

Anticipate Risk and Benefit;

PMS:There are however, risks that are currently unforeseeable. The only item in contact with
the skin is an pen shape optical probe. The optical powers we will use in this study are all
far less than those used with surgical lasers. The measurement itself is painless, and there
are no significant discomfort.

There are no benefit in this study. However,the knowledge gained from this study may be
benefit for the future skin treatment

MI;There are no risks associated with the use of near infrared light. The light is gathered
by a camera taking picture of the skin without contact the skin.

There are no benefit in this study. However,the knowledge gained from this study may be
benefit for the future skin treatment


Inclusion Criteria:



- Male or female age > 18 years

Exclusion Criteria:

- current participation in any other investigational drug evaluation

- inability to understand and carry out instructions

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Principal Investigator

John S Nelson, M.D,Ph.D

Investigator Role:

Principal Investigator

Investigator Affiliation:

Beckman Laser Institue, University of California Irvine

Authority:

United States: Institutional Review Board

Study ID:

RR-01192,AR-47551,HL-64218,

NCT ID:

NCT00540566

Start Date:

June 1999

Completion Date:

July 2008

Related Keywords:

  • Malignant Melanoma,
  • Merkel Cell Carcinoma,
  • Basal Cell Carcinoma,
  • Squamous Cell Carcinoma
  • Atypical Nevi,
  • Congenital Nevi
  • Seborrheic Keratosis,
  • Paget's Disease
  • Dermatofibroma,
  • Kaposi's Sarcoma
  • Hypervascular Congenital Malformations
  • Port Wine Stain
  • Hemangioma
  • Tattoos
  • Scleroderma
  • Burns
  • Normal Skin
  • Congenital Abnormalities
  • Histiocytoma
  • Histiocytoma, Benign Fibrous
  • Carcinoma
  • Carcinoma, Basal Cell
  • Carcinoma, Merkel Cell
  • Carcinoma, Squamous Cell
  • Scleroderma, Systemic
  • Scleroderma, Diffuse
  • Hemangioma
  • Keratosis
  • Keratosis, Actinic
  • Keratosis, Seborrheic
  • Melanoma
  • Nevus
  • Nevus, Pigmented
  • Sarcoma, Kaposi
  • Dysplastic Nevus Syndrome
  • Port-Wine Stain
  • Sarcoma

Name

Location

Beckman Laser Institute, Unversity of California IrvineIrvine, California  92612