Inclusion Criteria:

1. Written informed consent

2. Histologically or cytologically confirmed metastatic or advance-stage solid tumor
that has progressed following standard therapy or for which, in the opinion of the
Investigator, no standard effective therapy is available; patients without brain
metastases may be enrolled into the dose-escalation part of the study

3. Patients enrolled into the expanded MTD cohort must have shown unequivocal evidence
of brain metastases

4. Male and female patients.

5. Age ≥18 years

6. Eastern Cooperative Oncology Group (ECOG) performance status 0-2

7. An expected survival of at least 3 months

8. Measurable disease according to RECIST criteria; patients with brain metastases must
have at least one measurable lesion in the brain, according to RECIST criteria

9. Male and female subjects who are not surgically sterile or post-menopausal must agree
to use reliable methods of birth control for the duration of the study and for 90
days after the last dose of study drug administration; male partners of female
subjects should use condoms for the duration of the study, and for 90 days after the
last dose of study drug administration

Exclusion Criteria:

1. Chemotherapy, radiotherapy (except palliative radiation delivered to <20% of bone
marrow), or investigational agents within 4 weeks before the first dose of study
drug. Biologic therapy (such as 13-cis-retinoic acid, thalidomide, tamoxifen,
celebrex, erlotinib, imatinib, vorinostat, and lapatinib) and immunotherapy (such as
interferon a or b, cdx-110 (EGFR vIII vaccine), interleukin 2, thalidomide) within 1
week before the first dose of study drug. Bevacizumab within 6 weeks before the first
dose of study drug

2. Pregnant or lactating females

3. Any acute viral, bacterial, or fungal infection that requires parenteral therapy
within 14 days prior to study treatment

4. Known severe hypersensitivity to paclitaxel

5. Severe toxicity with previous taxane treatment

6. Treatment with P450 CYP 3A4 or CYP 2C8 enzyme-inducing anti-convulsant drugs within
14 days prior to treatment with study drug

7. Patients with inadequate hematological, liver, and renal function

8. Known or suspected acute or chronic active Hepatitis B, Hepatitis C, or HIV/AIDS

9. Patients with unstable or uncompensated respiratory, cardiac, hepatic or renal
disease or any other organ system dysfunction, medical condition, or laboratory
abnormality which, in the opinion of the Investigator, would either comprise the
patient's safety or interfere with the evaluation of the test material

10. Evidence of persistent Grade 2 or greater neurotoxicity