Know Cancer

or
forgot password

GLACIER: A Study to Investigate the Genetics of LobulAr Carcinoma In Situ in EuRope


N/A
N/A
60 Years
Open (Enrolling)
Female
Breast Cancer

Thank you

Trial Information

GLACIER: A Study to Investigate the Genetics of LobulAr Carcinoma In Situ in EuRope


OBJECTIVES:

Primary

- Identify inherited variation that predisposes women to develop lobular carcinoma in
situ (LCIS) of the breast.

- Identify the frequency of these variants and determine the effect they have on tumor
risk.

- Determine how worthwhile it would be to test for these variants in the clinical setting
so that those at higher risk could be identified, counseled, and screened.

Secondary

- Analysis of genetic changes within LCIS with the aim of identifying cases of LCIS which
may progress to invasive cancer.

OUTLINE: Patients and control participants undergo blood collection. DNA is extracted from
blood samples and used to genotype at selected polymorphisms, compare allele frequencies
(used to associate alleles with disease) using a genome-wide single nucleotide polymorphism
(SNP) screen. Archival tumor samples (if available) from patients are used for DNA-, RNA-,
or protein-based analyses.

All participants complete a questionnaire about family history, a brief medical history, and
provide epidemiological data to a genetic counselor. Participants identified to be at risk
for known hereditary predisposition to cancer will be referred to a clinical genetics
service. Individual results of this study are not disclosed to participants.

Peer Reviewed and Funded or Endorsed by Cancer Research UK.

PROJECTED ACCRUAL: A total of 2,000 participants (1,000 patients and 1,000 matched controls)
will be accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Meets 1 of the following criteria:

- Current or prior diagnosis of lobular carcinoma in situ (LCIS) of the breast,
including any of the following cases:

- Pure LCIS

- LCIS with subsequent development of invasive breast cancer of any
morphological subtype

- LCIS presenting as an incidental finding together with invasive breast
cancer of any morphological subtype

- Control participant matched for age and ethnicity to each LCIS patient

- Not affected by LCIS

- No history of ductal carcinoma in situ of the breast

- No breast cancer

- No relative (up to 2nd degree) who has been affected by breast cancer

- Male or female

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Inherited variation predisposing development of lobular carcinoma in situ (LCIS) of the breast in women

Principal Investigator

Elinor Sawyer, MD

Investigator Role:

Study Chair

Investigator Affiliation:

London Research Institute

Authority:

Unspecified

Study ID:

CDR0000566209

NCT ID:

NCT00536718

Start Date:

June 2007

Completion Date:

Related Keywords:

  • Breast Cancer
  • invasive lobular breast carcinoma with predominant in situ component
  • invasive lobular breast carcinoma
  • lobular breast carcinoma in situ
  • Breast Neoplasms
  • Carcinoma
  • Carcinoma in Situ
  • Carcinoma, Lobular

Name

Location