Women's Cancer Center Protocol #52: Alterations in Serum Serotonin Levels as a Mechanism for Chemotherapy Induced Constipation
- To determine if there are any alterations in serotonin levels in patients undergoing
chemotherapy for ovarian, fallopian tube, or primary peritoneal cancer and if this is
associated with increased constipation.
OUTLINE: Patients undergo blood sample collection prior to beginning of planned
postoperative chemotherapy, after 3 and 6 courses of chemotherapy, and at the 3-month
surveillance visit. Patients also complete a bowel function questionnaire at these time
Observational Model: Cohort, Time Perspective: Prospective
Alterations in serotonin levels associated with increased constipation
Once the blood is drawn at the time of another necessary blood draw, the specimen will be labeled as a send out lab in the acute care lab. These are frozen and batched. Batched samples will then be sent to an outside laboratory for serotonin measurements.
PreDose, Post 3rd Cycle, Post Treatment and 4 Months Post Treatment
Melissa A. Geller, MD
Masonic Cancer Center, University of Minnesota
United States: Institutional Review Board
|Masonic Cancer Center at University of Minnesota||Minneapolis, Minnesota 55455|