Inclusion Criteria

Inclusion criteria:

1. Age ≥ 18 years

2. Must have histologically or cytologically confirmed advanced or metastatic incurable
solid tumor as documented by CT or MRI that has progressed on or following standard
therapies

3. Must have failed prior standard systemic therapy

4. Must have at least one measurable and/or non-measurable lesion as defined by RECIST
criteria

5. Baseline MUGA or ECHO must demonstrate LVEF ≥ the lower limit of the institutional
normal.

6. Written informed consent obtained prior to any screening procedures

7. Willingness to have multiple blood draws

8. Ability to swallow capsules or tablets

Exclusion criteria:

1. Uncontrolled brain metastases

2. Prior treatment with an HDAC inhibitor

3. Presence of clinically detectable third-space fluid collections (e.g., ascites or
pleural effusions) that can not be controlled by drainage or other procedures prior
to study entry

4. Concomitant use of any anti-cancer therapy, including radiation therapy

5. Significant cardiac disease

6. Concomitant use of drugs with a risk of causing torsades de pointes

7. Impairment of gastrointestinal (GI) function or GI disease that may significantly
alter the absorption of oral LBH589

8. Previous use of monoamine oxidase inhibitors (e.g. clorgyline, iproniazid,
isocarboxazid, moclobemide, sibutramine, phenelzine, tranylcypromine) within 14 days
prior to the first dose of dextromethorphan