Inclusion Criteria

DISEASE CHARACTERISTICS:

- Diagnosis of 1 of the following:

- Acute myeloid leukemia (AML)

- Failed remission induction therapy or in relapse beyond second remission

- In first remission with poor risk cytogenetics (e.g., 11q abnormalities,
-7, -5, complex abnormalities [i.e., > 3 abnormalities, 6;9 translocation
and 3q abnormalities del (7q), del (5q), complex abnormalities ≥
abnormalities, 9q, 20q, 21q, 17q, t(9;21)])

- Acute lymphoblastic leukemia (ALL)

- Failed remission induction therapy or in relapse beyond second remission

- Blastic phase chronic myelogenous leukemia

- Refractory anemia with excess blasts

- Refractory anemia with excess blasts in transformation

- HLA -A, -B, -C, -DR identical sibling donor match available

- No relapse after prior bone marrow transplantation

PATIENT CHARACTERISTICS:

- Cardiac ejection fraction ≥ 50%

- Serum creatinine ≤ 1.2 times upper limit of normal (ULN) or creatinine clearance > 80
mL/min

- Bilirubin ≤ 1.5 times ULN

- AST and ALT < 5 times ULN

- FEV_1 ≥ 50% of predicted normal

- DLCO ≥ 50% of predicted normal

- No psychological or medical condition that would preclude allogeneic transplantation
(in the opinion of the treating physician)

- Not pregnant

- Negative pregnancy test

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- At least 28 days since prior induction or reinduction therapy

- Prior etoposide and busulfan allowed

- No prior radiation therapy that would exclude total-body irradiation