Neurocognitive Functioning in Adults With Upper Aerodigestive System Cancers
- To establish an estimate of the prevalence of baseline neurocognitive impairment prior
to initiation of outpatient cancer treatment.
- To establish an estimate of the incidence of neurocognitive impairment during
outpatient cancer treatment.
- To describe how neurocognitive functioning changes over time during cancer treatment.
- To identify sociodemographic and clinical factors associated with neurocognitive
- To examine health-related outcomes associated with neurocognitive impairment.
OUTLINE: Patients undergo interview to complete measures of domain-specific neurocognitive
functioning, global neurocognitive functioning, subjective neurocognitive functioning,
delirium, physical functioning, symptom prevalence and distress, mood states, and
medications at baseline before initiation of cancer treatment, at scheduled treatment
visits, and at the follow-up visit 3 months after completion of cancer treatment.
Measures of comorbidity, alcohol use, sensory functioning (vision and hearing), and
sociodemographic are completed at baseline only. Cancer-related information (diagnosis,
staging, and sites of metastasis, if applicable), treatment-related information (planned
treatment regimen - chemotherapy and/or radiation therapy), and current medications are
obtained at baseline by medical record review.
Health service use and complications are assessed at each scheduled treatment visit and at
the 3-month post-treatment follow-up visit. Measures of domain-specific neurocognitive
functioning, coping, and quality of life are completed at baseline and at the 3-month
Observational Model: Cohort, Time Perspective: Prospective
Domain-Specific Neurocognitive Functioning measuring attention, executive functioning, mental processing speed, verbal memory, language, and visuospatial construction at baseline and 3 months after completion of treatment
Baseline and 3 months post-treatment
Stewart M. Bond, PhD, RN
Vanderbilt-Ingram Cancer Center
United States: Federal Government
|Vanderbilt-Ingram Cancer Center||Nashville, Tennessee 37232-6838|
|MBCCOP - Meharry Medical College - Nashville||Nashville, Tennessee 37208-3599|
|Vanderbilt-Ingram Cancer Center - Cool Springs||Nashville, Tennessee 37064|
|Vanderbilt-Ingram Cancer Center at Franklin||Nashville, Tennessee 37064|