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NYU Ovarian Cancer Early Detection Program Blood and Genetics


N/A
18 Years
N/A
Not Enrolling
Female
Ovarian Cancer

Thank you

Trial Information

NYU Ovarian Cancer Early Detection Program Blood and Genetics


The aim of NYU Ovarian Cancer Early Detection Program is to establish an effective, early
detection program employing state-of-the-art science and technology in collaboration with
other nationally recognized clinicians and scientists.

This proposed research study will foster collaboration between clinicians and scientists
that will facilitate the rapid identification of a set of molecular, biochemical,
functional, and genetic markers which can be employed to effectively detect and manage
ovarian cancer and other gynecological malignancies.


Inclusion Criteria:



Women enrolled in the NYU Ovarian Cancer Early Detection Program have at least one of the
following risk factors:

- A personal history of breast cancer

- One or more first degree relatives (mother, sister, daughter) with ovarian cancer

- Multiple family members with either breast and/or ovarian cancer

- A personal history of a positive BRCA1 or BRCA2 genetic test result

- A close relative with a positive BRCA1 or BRCA2 genetic test result

- A personal history of colon or endometrial cancer with at least two relatives with a
Lynch/HNPCC-associated cancer (colorectal, endometrial, small bowel, ureter, or renal
pelvis cancer)

- Synchronous or metachronous endometrial and colorectal cancer

- A personal history of a mismatch repair gene mutation (MLH1, MSH2, MSH6 or PMS2)

- A close relative with a mismatch repair gene mutation (MLH1, MSH2, MSH6 or PMS2)

- A personal history of colorectal or endometrial cancer with a mismatch repair defect
(ie. Microsatellite instability (MSI) or immunohistochemical loss of expression of
MLH1, MSH2, MSH6, or PMS2)

- The use of fertility drugs for more than one year

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

identification and development of highly sensitive and specific tumor markers for ovarian cancer

Outcome Time Frame:

5 years

Safety Issue:

No

Principal Investigator

Bhavana Pothuri, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

New York University School of Medicine

Authority:

United States: Institutional Review Board

Study ID:

NYU 04-30 H11938

NCT ID:

NCT00531778

Start Date:

June 2004

Completion Date:

November 2010

Related Keywords:

  • Ovarian Cancer
  • Women with increased risk for developing ovarian cancer
  • early detection
  • biomarker for ovarian cancer
  • Ovarian Neoplasms

Name

Location

NYUCancer Institute Clinical Cancer CenterNew York, New York  10016