Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain: A Randomized, Double-Blind Study
18 Years
N/A
Both
Cancer, Pain, Palliative Care
Trial Information
Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain: A Randomized, Double-Blind Study
Opioids are the mainstay of moderate-to-severe cancer pain management. Although morphine is
the most commonly used, methadone has some advantages such as higher potency, lower cost and
longer administration intervals. To minimize the time necessary to achieve the equianalgesic
effect after a switching from morphine to methadone, acetaminophen was added in the
treatment.
Inclusion Criteria:
- Clinical diagnosis of cancer pain
- Regular use of oral Morphine
Exclusion Criteria:
- Use of Acetaminophen in the last 48 hours
- Renal or Hepatic failure
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Supportive Care
Outcome Measure:
Pain intensity and time to equianalgesic effect
Outcome Time Frame:
within the first 7 days after switching
Principal Investigator
Daniel IG Cubero
Investigator Role:
Principal Investigator
Investigator Affiliation:
Faculdade de Medicina do ABC
Authority:
Brazil: National Committee of Ethics in Research
Study ID:
217/2005
NCT ID:
NCT00525967
Start Date:
February 2006
Completion Date:
October 2007
Related Keywords:
- Cancer
- Pain
- Palliative Care
- Cancer Pain
- Methadone
- Morphine
- Acetaminophen
- Palliative Care
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