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A Phase II Study of Docetaxel, Oxaliplatin and S-1 (DOS) in Patients With Advanced Gastric Cancer

Phase 2
18 Years
70 Years
Not Enrolling
Stomach Neoplasms

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Trial Information

A Phase II Study of Docetaxel, Oxaliplatin and S-1 (DOS) in Patients With Advanced Gastric Cancer

Docetaxel is an anti-microtubule agent. Docetaxel is an active agent for gastric cancer,
with response rate (RR) of 20-24% as a single agent and RR of 37-40% as a combination
therapy with 5-FU and/or cisplatin.

S-1 is a new oral dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine (DIF).
In two late phase II studies of S-1 for advanced gastric cancer, RR was 45%, with very low
(2%) incidence of grade 3 toxicity.

Recent phase I/II trial of the combination of docetaxel and S-1 in patients with advanced
gastric cancer suggests that repeated 3-4 week cycles of S-1 60-80mg/m2 /day for 14 days
combined with docetaxel 40-75mg/m2 is feasible.

Oxaliplatin, diaminocyclohexane-platinum, is an alkylating agent inhibiting DNA replication.
Comparing to cisplatin or carboplatin, oxaliplatin appear to be more effective and has a
more favorable toxicity profile. Phase II studies of the combination of docetaxel and
oxaliplatin in patients with advanced gastric cancer suggests that docetaxel 60 or 75mg/m2
combined with oxaliplatin 130 or 80mg/m2 every 3 weeks is feasible.

Recent dose finding study of the combination of docetaxel, oxaliplatin and S-1 (DOS) in
patients with advanced gastric cancer suggests that docetaxel 52.5mg/m2 on day 1 and
oxaliplatin 105mg/m2 on day 1 combined with S-1 80mg/m2 on day1 to day 14 every 3 weeks is

Docetaxel, S-1 and oxaliplatin have distinct mechanisms of action and no overlapped key
toxicities. Furthermore, fluoropyrimidine and docetaxel or oxaliplatin have shown synergism
in vivo studies and in clinical trials. Based on these results, the combination of DOS is a
reasonable candidate of new chemotherapeutic regimen for the advanced gastric cancer.

Inclusion Criteria:

- Histologically confirmed gastric adenocarcinoma, initially diagnosed or recurred

- Unresectable, locally advanced or metastatic

- At least one uni-dimensional measurable lesion by RECIST criteria

- Age 18 to 70 years old

- ECOG performance status ≤2

- Estimated life expectancy ≥3 months

- Adequate bone marrow function (WBCs ≥4,000/µL or absolute neutrophil count
≥1,500/µL, platelets ≥100,000/µL),

- Adequate kidney function (creatinine <1.5 mg/dL)

- Adequate liver function (bilirubin ≤1.8 mg/dL, transaminase levels <2 times the upper
normal limit

- Written informed consent

Exclusion Criteria:

- Other tumor type than adenocarcinoma

- Previous history of chemotherapy (exception: adjuvant chemotherapy)

- Presence of CNS metastasis, psychosis, or seizure

- Obvious bowel obstruction

- Evidence of serious gastrointestinal bleeding

- Peripheral neuropathy (NCI CTC >= Grade I)

- Past or concurrent history of neoplasm other than gastric adenocarcinoma, except for
curatively treated non-melanoma skin cancer or in situ carcinoma of the cervix uteri

- Pregnant or lactating women, women of childbearing potential not employing adequate

- Other serious illness or medical conditions

Type of Study:


Study Design:

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

overall response rate

Outcome Time Frame:

2.5 years

Safety Issue:


Principal Investigator

Dae Young Zang, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Hallym University Medical Center


Korea: Food and Drug Administration

Study ID:




Start Date:

August 2007

Completion Date:

June 2010

Related Keywords:

  • Stomach Neoplasms
  • Stomach Neoplasm
  • Docetaxel
  • Oxaliplatin
  • S-1
  • Neoplasms
  • Stomach Neoplasms