Inclusion Criteria:

- Adult participants (18 years of age or older)

- Able to give written informed consent

- Anticipated episode(s) of incident pain related to planned BMB lasting no more than
30 minutes on average

- Anticipated life expectancy of at least 1 month

Pre-Exclusion Criteria:

- Subjects with a clinical condition that may, in the opinion of the investigator,
impact on the subject's ability to participate in the study, or on the study results

- Participants who have had IV sedation/opioid on previous BMB and who wish to receive
IV sedation/opioid on this occasion or who in the opinion of the BMB operator would
be advised to receive IV sedation/opioid on this occasion

- Concomitant use of other investigational agents

- Concomitant use of nephrotoxic agents such as gentamicin

- Uncontrolled INR (>4)

- Personal or familial hypersensitivity to fluorinated anaesthetics

- Personal or familial malignant hyperthermia

- Respiratory rate of less than 10 per minute

- Has previously received methoxyflurane

- Known pre-existing renal or hepatic impairment

- Compromised Renal Function (creatinine ≥ 1.5 x ULNR)

- Compromised Liver Function (bilirubin ≥ 2.5 x ULNR)

Exclusion Criteria:

- Premedication with anxiolytic (e.g. midazolam, diazepam)

- Dosed with breakthrough dose of analgesic that may contribute to control of pain
during the planned procedure