Inclusion Criteria:

- Histologically confirmed recurrent or metastatic ovarian carcinoma, fallopian tube
carcinoma, primary peritoneal carcinoma, cervical carcinoma, endometrial carcinoma,
vulvar carcinoma, vaginal carcinoma, or carcinosarcoma of the ovary, endometrium or
cervix.

- Prior Therapy: at least one and may have up to three prior cytotoxic chemotherapeutic
regimens for the management of primary disease.

- Must be at least 18 years of age.

- GOG performance status must be 0 or 1.

- Patients must have adequate organ and marrow function as defined below:

- hemoglobin ≥10g/dL

- absolute neutrophil count ≥1,500/uL

- platelets ≥100,000/uL

- total bilirubin below the institutional upper limit of normal

- AST(SGOT)/ALT(SGPT) below the institutional upper limit of normal

- creatinine below the institutional upper limit of normal

- cholesterol ≤ 350 mg/dL (fasting)

- triglycerides ≤ 400 mg/dL (fasting)

- albumin ≥ 3.0 mg/dL

- negative pregnancy test for women able to have children

- Ability to understand and the willingness to sign a written informed consent
document.

Exclusion Criteria:

- Prior therapy with topotecan

- More than 3 prior cytotoxic chemotherapeutic regimens or treatment with temsirolimus
or any other mTOR inhibitor

- Concomitant hormonal therapy or radiation therapy

- Clinically significant infections or other medical problems of significant severity

- History of unstable angina or myocardial infarction within the past six months

- Known brain metastases unless the metastases have been controlled by prior surgery or
radiotherapy, and the patient has been neurologically stable and off of steroids for
at least 4 weeks.

- Any requirement for oxygen

- Cannot be receiving potent enzyme-inducing antiepileptic drugs (EIAEDs; e.g.,
phenytoin, carbamazepine, phenobarbital) nor any other potent CYP3A4 inducer such as
rifampin or St. John's wort, as these may decrease temsirolimus levels. Use of agents
that potently inhibit CYP3A4 (and hence may raise temsirolimus levels), such as
ketoconazole, is discouraged, but not specifically prohibited.