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Physical Activity and Its Components in Relation to Plasma Inflammatory Markers of Cancer Risk Among Chinese Adults

40 Years
70 Years
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Trial Information

Physical Activity and Its Components in Relation to Plasma Inflammatory Markers of Cancer Risk Among Chinese Adults

In the past decade, China has experienced fundamental decreases in the populations' physical
activity levels, due to increasingly sedentary occupations and lifestyles. However, the
transition to a Western lifestyle has not reached the entire Chinese population. The
resulting wide range of between-person variation in physical activity provides an
unparalleled opportunity for physical activity studies. Although physical activity
measurement techniques have evolved considerably over the past years, the main obstacle in
quantifying physical activity is the complexity of precisely measuring its individual
components, particularly low to moderate-intensity activities.

Recently, investigators at Vanderbilt University, the Shanghai Cancer Institute, and the
DCEG initiated two prospective population-based cohort studies: the Shanghai Women's Cohort
and the Shanghai Men's Cohort. The aim of these studies is to prospectively examine the
relations of diet, lifestyle, occupational, and environmental risk factors, as well as
genetic variation, to cancer incidence among 75,000 women and 73,000 men, aged 40 to 70
years old, and residing in Shanghai, China. We propose to coduct a study among 600 women and
men participating in these two cohort studies. The specific objectives of the current study
are to develop a comprehensive physical activity questionnaire and to assess the validity
and reliability of this instrument in the Shanghai cohorts using objective measures of
physical activity/physical fitness: activity monitors, and the Modified Canadian Aerobic
Fitness Test. In addition, we intend to evaluate whether different types and parameters of
physical activity are associated with circulating levels of specific inflammatory markers
that have been linked to cancer risk. The specific markers are C-reactive protein (CRP),
interleukin 6 (IL-6), and soluble tumor necrosis factor alpha (TNF-a). The impact of
potentially confounding variables of the association between physical activity and
inflammatory markers, such as recent exercise, use of anti-inflammatory drugs, and current
or recent infections, will be carefully accounted for in the analysis.

Inclusion Criteria


The current study will be conducted in random sub samples of the Shanghai Women's Cohort
Study and Shanghai Men's Cohort Study. Eligibility in these 2 cohort studies was
determined based on the following: 40 to 70 years of age and residing in one of 7 Shanghai
urban areas that is representative of all of urban Shanghai. Both women and men will be
included in the study. No exclusions will be made by race, although it should be noted
that the study population of the Shanghai Women's Cohort and Shanghai Men's Cohort Study
is virtually 100% Asian.


There wil be no prior from participation, other than the presence of physical ailments
preventing subjects from participating in the study. Before participating in the fitness
test, subjects will be screened for cardiovascular disease, othopedic limitations, or
other factors that contraindicate testing, including pregnancy, respiratory problems at
rest (labored breathing or persistent cough), presence of illness or fever, or swelling of
the lower extremities. In addition, participants who do not adhere to the pre-test
instructions of not eating heavily or drinking alcohol 2 hours before the test will be
excluded from performing the fitness test.

Children will not be included in the current study, because study subjects are comprised
of participants in the Shanghai Womens's Cohort Study and the Shanghai Men's Cohort Study,
who are 40 to 70 years of age.

Type of Study:


Study Design:


Principal Investigator

Charles E Matthews, Ph.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Cancer Institute (NCI)


United States: Federal Government

Study ID:




Start Date:

July 2005

Completion Date:

Related Keywords:

  • Cancer
  • Physical Fitness
  • Energy Expenditure
  • Nutrition Transition
  • Biomarker
  • Activity Monitors
  • Cancer Risk