Inclusion Criteria:
- More than 18 years old.
- Epidermoïde carcinoma or adenocarcinoma of the cervix, hystologic proved
- Patientes in a late stage or with progresive desease.
- One mesurable lesion in irradiated zone.
- Patient who have already treated radio-chimiothérapy with platine should have a 6
month free interval.
- Index status of ECOG (" Eastern Cooperative Oncology Group ")less than 2.
- Good biologicals and hematologicals fonctions:
- Neutrophiles noless than 1,5.109/L.
- Platelets nolss than 100.109/L.
- Total bilirubin no more than 1,5 time the normal superior range.
- Transaminases no mote than 3 x Time NSR
- Creatinine clairance Cockroft) more than 50 mL/min .
- Inform consent signed.
Exclusion Criteria:
- Previous cytotoxic traitement exept radio-chaemiotherapy of the pelvis cerebrals
metastasis.
- Other cancer in the last 5 years exept treated BCC.
- Dermatologic desease.
- Crohn desease or Hemorragic rectal-Colitis.
- Neuropathy.
- Psychologic disorder.
- Social troubles.
- Pregnant women.