Radiation Therapy as Palliative Treatment of GIST Progressing During or After Tyrosine Kinase Inhibitor Therapy: A Prospective Study
Radiation therapy planning must be based on computerized tomography (CT). External beam
radiation must be used. Both 3D and IMRT plans are acceptable. The cumulative radiation dose
may range from 30 to 40 Gy as administered in 1.8 to 2.0 Gy fractions, 5 fractions per week.
The dose is specified as defined by the ICRU (International Commission on Radiation Units
and Measurements) report 50. Response is evaluated using CT 6 and 12 weeks after
irradiation. Adverse effects are evaluated using the Common Terminology Criteria for Adverse
Effects (CTCAE)version 3.
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Target tumor response rate
6 to 12 weeks
Heikki Joensuu, M.D., Ph.D.
Department of Oncology, Helsinki University Central Hospital
Finland: Ministry of Social Affairs and Health