Inclusion Criteria:

- Advanced Stage Endometrial Cancer (Stage 3 or 4)

- Any Histology including clear cell, and serous papillary carcinomas

- surgery must have had hysterectomy and bilateral salpingo-oophorectomy

- chemotherapy initiated 12 weeks after surgery

- sign informed consent

- Adequate End-organ function

- GOG Performance Status 0,1,2

- Patients must be 18 years or older

- Patients may have received radiation for the treatment of endometrial cancer.

- Patients may have measurable or non-measurable disease.

Exclusion Criteria:

- Patient with concomitant malignancy other than non-melanoma skin cancer

- Patients with prior malignancy who have been disease free for 5 years.

- Patients with serious uncontrolled infection, angina or serious peripheral
neuropathy.

- Patients whose circumstances will not permit study completion or adequate follow up

- Patients who have received prior cytotoxic chemotherapy for treatment of endometrial
cancer including chemotherapy used for radiation sensitization.