A Pilot Study of Early Changes in DNA Array Expression Following Chemo-Radiation Treatment of Cervical Cancer
Patients in this study are already scheduled to begin radiation therapy. Researchers will
get tumor cells by taking two biopsies of the cervix. The first biopsy of the cervical
tumor will be done before any treatment is given.
The second biopsy will be performed about 48 hours after the radiation treatment has begun.
They will then study the cells in the lab with a new technique for studying gene expression
called DNA array, as well as HPV analysis, quantification of apoptosis levels, hematoxilin
and eosin staining, and storage of tissue for future research..
The patterns of gene expression in the biopsies will be compared with the success of
Some of the material will also be stored and used in the future for other research projects.
This is an investigational study. A total of 18 patients will take part in this study. All
will be enrolled at UTMDACC.
Observational Model: Case-Only, Time Perspective: Prospective
The goal of this clinical research study is to find out if the expression of certain genes is linked with the response of cervical cancer to radiation.
Anuja Jhingran, MD
M.D. Anderson Cancer Center
United States: Institutional Review Board
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