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Standard of Care Trial: Unrelated Stem Cell Transplantation for Adults With Hematopoietic Disorders


N/A
16 Years
54 Years
Not Enrolling
Both
CML, ALL, AML, Myelodysplasia, Lymphoma, Myeloproliferative Disorders

Thank you

Trial Information

Standard of Care Trial: Unrelated Stem Cell Transplantation for Adults With Hematopoietic Disorders


This protocol identifies a standard-of-care method for unrelated stem cell transplantation
in adults. Performing this service in a consistent and documented fashion allows
investigators to obtain informed consent from recipients. Data is tabulated locally for
quality-control comparisons with nationally-reported standards. As a condition of
maintaining transplant center status and to have acess to NMDP-registered donors, UCSF
submits clinical and outcome data to the NMDP. As a result, UCSF is contributing to the
resolution of remaining uncertainties regarding particular transplantation practices.


Inclusion Criteria:



- Age >15 and <55

- Adequate renal function with serum creatinine <2.0 mg/dl

- Pulmonary diffusing capacity>50% of predicted

- Cardiac ejection fraction >40% as measured by radionuclide wall motion study or
echocardiography

- Total bilirubin must be <2.5 mg/dl.

- Alkaline phosphatase and AST must be less than three times the upper limit of normal

- Negative serology for the human immunodeficiency virus

- Available HLA-matched donor

- Signed informed consent

Exclusion Criteria:

- No fully or single-antigen-mismatched sibling donor is available to donate stem cells

- No active liver disease.

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Principal Investigator

Thomas G. Martin, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of California, San Francisco

Authority:

United States: Institutional Review Board

Study ID:

UC-9907-CC99251

NCT ID:

NCT00511537

Start Date:

January 1999

Completion Date:

June 2009

Related Keywords:

  • CML
  • ALL
  • AML
  • Myelodysplasia
  • Lymphoma
  • Myeloproliferative Disorders
  • AML
  • ALL
  • CML
  • Lymphoma
  • Myelodysplasia
  • Unrelated stem cell transplantation
  • Hematopoietic disorders
  • Lymphoma
  • Myelodysplastic Syndromes
  • Preleukemia
  • Myeloproliferative Disorders

Name

Location

University of California San FranciscoSan Francisco, California  941104206