Inclusion Criteria

Inclusion Criteria for chronic phase patients :

1. Age >/=18 years

2. Ph positive

3. Absence of a CHR after 3 months on imatinib

4. Loss of a previously obtained CHR on imatinib alone

5. Absence of a CCgR within 12 months on imatinib alone

6. Loss of a previously obtained CCgR on imatinib alone

7. Written informed consent

Exclusion Criteria for chronic phase patients :

1. Age <18

2. Performance status (ECOG/WHO) > 2 (see Appendix 2)

3. Inability to provide written informed consent

4. Pregnancy

5. Accelerated or blastic phase

6. Formal refusal of any recommendation of a safe contraception

7. Alcohol or drug addiction

8. Altered hepatic or renal function as defined by AST/ALT or bilirubin > 3 times upper
normal limits (UNL)

9. Serum creatinine > 265 umol/l or >3.0 mg/dl

10. Any other disease or condition that by the advise of the responsible physician would
make the treatment dangerous for the patient or would make the patient ineligible for
the study, including physical, psychiatric, social and behavioural problems.

Inclusion criteria for accelerated and blastic phase or acute lymphoblastic leukemia Ph+
patients:

1. Age >/=18 years

2. Ph positive

3. Loss of a previous hematological response to imatinib alone, with further progression
to ABP (see section 14 for definitions)

4. Performance status (ECOG/WHO)

5. Written informed consent

Exclusion criteria for accelerated and blastic phase or acute lymphoblastic leukemia Ph+
patients:

1. Age <18

2. Performance status (ECOG/WHO) > 2 (see Appendix 2)

3. Inability to provide written informed consent

4. Pregnancy

5. Chronic Phase disease

6. Formal refusal of any recommendation of a safe contraception

7. Alcohol or drug addiction

8. Altered hepatic or renal function as defined by AST/ALT or bilirubin > 3 times upper
normal limits (UNL)

9. Serum creatinine > 265 umol/l or >3.0 mg/dl

10. Any other disease or condition that by the advise of the responsible physician would
make the treatment dangerous for the patient or would make the patient ineligible for
the study, including physical, psychiatric, social and behavioural problems.