Inclusion Criteria:

- Patients with resectable colorectal cancer must have samples collected (serum/urine)
prior to surgery and/or after surgery, but prior to starting chemotherapy.

- Patients with metastatic colorectal cancer must have samples collected prior to
initiating chemotherapy, and after chemotherapy initiation: every 3 months for up to
24 months.

- Subjects must be ≥ 18 years of age.

- Subjects undergoing screening colonoscopy are able to participate as healthy controls
or as patients with colon polyps if colonoscopy identifies colon polyps being present
(informed consent will be signed first and samples will be collected; after
colonoscopy the samples will be identified as "healthy" or "polyps").

- For patients who underwent biopsy or surgery for colorectal cancer, enough tissue
needs to be available for testing, as appropriate per patients groups in the protocol
Schema.

- Subjects must be able to attend follow up or treatment visits per investigator's
recommendations for up to 24 months for collection of serum/urine specimens.

- Female patients known to be pregnant are not eligible for this protocol.

- Subjects must be able to undergo an 8-hr overnight fast prior to metabolomic testing

Exclusion Criteria:

- Presence of an invasive cancer other than colorectal cancer is an exclusion criterion