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Phase 1 Study of Endometrial Markers of Endometrial Receptivity in Oocyte Donation

18 Years
51 Years
Not Enrolling
Embryo Implantation

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Trial Information

Phase 1 Study of Endometrial Markers of Endometrial Receptivity in Oocyte Donation

Since the introduction of In vitro fertilization (IVF), substantial improvements have been
developed in ovulation induction, oocyte retrieval, fertilization capability and embryonic
development. However, the end point which is to improve implantation and pregnancy rates
after transferring embryos, remains below physiological expectations. It has been estimated
that clinical implantation in the human is efficient in no more than 30% of cases
considering that only one embryo is present in natural cycles, which gives us a 30%
implantation rate.

A frequent pitfall found in the literature is the consideration that implantation is the
result of good embryonic quality. Although this is completely true, it is not the only truth
because the maternal endometrium is at least of equal relevance. In ovum donation, the
endometrial factor could also be improved by individualizing the implantation window in each
patient. In this proposed research we will analyze suggested markers of endometrial
receptivity in order to optimize human implantation in patients undergoing assisted
reproductive technologies focusing on improving endometrial receptivity in IVF and ovum
donation patients.

Inclusion Criteria:

- Patients scheduled for IVF or OD

Exclusion Criteria:

- Cervical stenosis

Type of Study:


Study Design:

Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

embryo implantation

Outcome Time Frame:


Principal Investigator

Ariel Revel, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:



Israel: Ministry of Health

Study ID:




Start Date:

August 2007

Completion Date:

Related Keywords:

  • Embryo Implantation
  • Embryo Implantation
  • Endometrium
  • endometrial implantation
  • Oocyte Donation
  • in vitro fertilization
  • endometrial sampling
  • Adenoma