Trial Information

Phase 1 Study of Endometrial Markers of Endometrial Receptivity in Oocyte Donation

Since the introduction of In vitro fertilization (IVF), substantial improvements have been
developed in ovulation induction, oocyte retrieval, fertilization capability and embryonic
development. However, the end point which is to improve implantation and pregnancy rates
after transferring embryos, remains below physiological expectations. It has been estimated
that clinical implantation in the human is efficient in no more than 30% of cases
considering that only one embryo is present in natural cycles, which gives us a 30%
implantation rate.

A frequent pitfall found in the literature is the consideration that implantation is the
result of good embryonic quality. Although this is completely true, it is not the only truth
because the maternal endometrium is at least of equal relevance. In ovum donation, the
endometrial factor could also be improved by individualizing the implantation window in each
patient. In this proposed research we will analyze suggested markers of endometrial
receptivity in order to optimize human implantation in patients undergoing assisted
reproductive technologies focusing on improving endometrial receptivity in IVF and ovum
donation patients.