Reflectance Confocal Imaging of Cervical Intraepithelial Neoplasia (CIN)
Confocal microscopy may be a new way to detect lesions of the cervix quickly without
removing a tissue sample. Women in the study will already be scheduled for colposcopy to
detect or treat cervical lesions. (A colposcopy is an exam of the vagina and cervix using a
Microscopic images will be taken during the routine colposcopy in the outpatient clinic. A
disinfected probe will be inserted into the vagina and placed against the cervix. . The
probe sends out laser light and detects reflected light from the tissue. Images of cervical
tissue will be formed and displayed on a computer monitor. 1-3 regions of the cervix will
be imaged (2 abnormal and one normal), and each will take about 1-2 minutes.
Each imaged site will be biopsied. The biopsies will be analyzed by the research
pathologist. The results will be available to participants in the event that care needs to
be given. Total participation in this study will be only a few minutes.
This is an investigational study. About 72 women will take part in this study. About 18
will be enrolled at M. D. Anderson.
Observational Model: Case-Only, Time Perspective: Prospective
Reflectance confocal images of cervical tissue in vivo
1-2 minutes during routine colposcopy
Michele Follen, MD, PhD
M.D. Anderson Cancer Center
United States: Institutional Review Board
|U.T.M.D. Anderson Cancer Center||Houston, Texas 77030|
|Lyndon B. Johnson Hospital||Houston, Texas 77030|
|U. T. Health Science Center||Houston, Texas 77030|