Liverpool Lung Project
- To prepare a molecular genetic and epidemiological risk assessment model based on the
analysis of environmental exposures and genetic predisposition, which will provide an
algorithm to measure an individual's risk for developing lung cancer.
- To develop an archive of specimens relating to at-risk individuals and those with lung
- To redefine lung cancer based on molecular pathology using the fields of expression and
methylation profiling, and genetic instability.
- To identify and assess novel markers of pre-carcinogenesis in our high-risk
- To facilitate the development of new intervention strategies (i.e., chemoprevention).
OUTLINE: This is a multicenter study.
Participants and/or patients undergo tumor tissue, sputum, and blood sample collection
periodically. Samples are analyzed via fields of expression and methylation profiling and
genetic instability. Samples are also archived.
Complete lifetime lifestyle, residential, environmental tobacco smoke, and occupational
history are assessed in the first year and then in year five and year ten. Participants who
return for follow-up complete a shorter questionnaire aimed at recording change over the
interval since their last attendance.
PROJECTED ACCRUAL: 800 patients and 7,500 healthy participants will be accrued for this
- Prospective cohort:
- All residents (n=326,000), aged 45-79, within the designated Liverpool postcode
study area will be eligible for entry into the study
- 7,500 people will be randomly selected from this population via general
practitioner's (GP's) lists held by each Primary Care Trust
- All the GP's who have practices within the study area will be asked to
collaborate with the project
- Patients: Newly diagnosed cases of primary lung cancer
- All cases of epithelial tumors of the trachea, bronchus, and lung will be
- Two controls per case who are matched for age (+/- 2 years) and gender and will
be randomly selected from the Liverpool Lung Project prospective cohort
Prepare a molecular genetic and epidemiological risk assessment model based on the analysis of environmental exposures and genetic predisposition, which will provide an algorithm to measure an individual's risk for developing lung cancer
John K. Field, MA, BDS, PhD, FRCPath
University of Liverpool Cancer Research Centre