Biomarkers of Genetic Susceptibility in Environmentally-Exposed Migrant/Seasonal Farmworker Women and Their Children
Participants in this study are either MSF children and their mothers or non-MSF women (women
who have never worked in agriculture) and their children. If a mother has more than one
child in the school system, only one child can participate in the study. A major effort of
this study is to collect, store and analyze blood and urine samples from MSF women children
and a group of non-MSF women and children. Only the MSF children will be matched by
ethnicity, sex, age (2 or more years), and place of residence to non-MSF children.
All mothers and children participants will be recruited from the school rosters of the Goose
Creek Consolidated Independent School District in Harris County, and the La Joya School
District in Hidalgo County. The names and addresses of all the children and their mothers
are also included in the rosters. Each mother will be contacted by a telephone call or
letter inviting her and her child to participate in the study. If they agree, they will
then be asked if they would like to complete the interview by telephone with the interviewer
from M. D. Anderson or prefer to do the interview at the on-site visit.
A bilingual interviewer will ask each child's mother if she and her child would like to
participate in the study. The interviewer will ask each participating mother about her and
her child's age, child's gender, her and her child's exposure to chemicals, medical history,
places they have lived, places she has worked, family history of disease, reproductive and
breast feeding histories, diet, alcohol and tobacco use. The interview will take from 60 to
70 minutes to complete the mother's and the child participants' questionnaires. All
interviews will be completed by telephone or on-site in the language of choice (English or
Two (2) members of the research team will collect the blood and urine samples, and transport
them to M. D. Anderson since an overnight carrier is not available on the required days of
collection. About 5 teaspoons of blood will be drawn and a urine sample will be collected.
In addition, the height and weight of the mothers and the children will be measured. All
blood and urine collected will be used only by the researchers involved in this study. If
the child's mother agrees, the type(s) and levels of the pesticides detected will be
provided to the child's physician for diagnostic purposes only. The data will be analyzed
in a way that will help maintain confidentiality.
This is an investigational study. A total of 400 children participants and their mothers
(N=400) will take part in this study. All 800 participants will be enrolled at UT MD
Anderson Cancer Center.
Observational Model: Case-Only, Time Perspective: Prospective
DNA damage [# of chromosome aberrations (CA)] calculated by exposure group
One time blood/urine collection from each mother/child
Maria A. Hernandez, MD
UT MD Anderson Cancer Center
United States: Institutional Review Board
|UT MD Anderson Cancer Center||Houston, Texas 77030|