Breast Cancer Risk Assessment Using Optical Breast Spectroscopy (OBS)
Preliminary data show Optical Breast Spectroscopy (OBS)has the ability to detect tissue
differences with various pathologies and age-related changes in breast tissue over a two
year period. In the present study, we want to determine whether OBS has the ability to
detect optical differences between women who harbor a mutation in the breast cancer
susceptibility gene, BrCa1 or BrCa2, and their age-matched controls (non-carriers). More
specifically, possible differences in the breast tissue at time of enrollment into the study
(reflecting changes potentially occurring in adolescence) and in the rate of breast tissue
change over time (reflecting rate of tissue transformation from normal to ultimately
malignant state). The overall goal is to develop a pre-screening technique to survey or
monitor the risk of breast tissue and to advise the earliest point when imaging techniques
(e.g. MRI) should be initiated or when more drastic primary prevention measures are
recommended.
Observational
Observational Model: Case Control, Time Perspective: Prospective
Lothar Lilge, PhD
Principal Investigator
Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9; Department of Biophysics and Bioimaging, University of Toronto, Toronto, Ontario, Canada M5G 2M9
Canada: Health Canada
UHNREB#07-0689-CE
NCT00500383
October 2009
April 2013
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