In-Hospital Individualized Prescriptive Exercise Intervention for Acute Leukemia Patients Undergoing Chemotherapy
- Determine the effects, in terms of fitness and blood parameters, fatigue levels, and
quality of life, of an individualized prescriptive exercise intervention in patients
with newly diagnosed acute or relapsed myeloid or lymphoblastic leukemia undergoing
- Determine the feasibility of developing an exercise program for these patients.
- Assess the changes in cardiovascular endurance, muscular strength, selected blood
parameters, and response of inflammatory proteins to exercise in these patients.
- Evaluate fatigue, depression, and quality of life of these patients.
OUTLINE: This is a pilot study.
Patients participate in an individualized prescriptive exercise intervention 3 to 4 times
per week for 6 weeks (4 weeks in hospital, 2 weeks at home). Exercise begins concurrently
with the first course (induction therapy) of chemotherapy. Each exercise session consist of
3-5 minutes of light stretching (stretching component), 5-10 minutes of cycling on the
recumbent bicycle (cardiorespiratory component), 5-15 minutes of resistance training
including hand dumbbells, exercise tubing, rubber bands, and fit balls (resistance training
component), and 5-10 minutes of abdominal exercises (core muscles component).
Quality of life, fatigue, and depression are assessed at baseline and weekly during study
Blood samples are collected at baseline and at weeks 3 and 6 for cytokine analysis.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Effects of an individualized prescriptive exercise intervention
All patients will participate in an individualized prescriptive exercise intervention 3 to 4 times per week (depending on the physical status of each patient during each week) for a period of 6 weeks. The exercise intervention will begin on week 1 of the study, the day after the first battery of initial assessments is concluded. Each exercise session will be divided into two bouts. One bout will be administered in the morning and the second one late in the afternoon
Claudio L. Battaglini, PhD
UNC Lineberger Comprehensive Cancer Center
United States: Institutional Review Board
|Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill||Chapel Hill, North Carolina 27599-7570|